The Indianapolis Colts look to continue their dominance over the Tennessee Titans after three consecutive sweeps, but can they maintain their edge against a revamped Titans squad featuring Carnell Tate and Wandale Robinson under new leadership from Robert Saleh and Brian Daboll? With the Colts boasting a 41-22 all-time record against the Titans, the stakes are high as they aim for another 2-0 run in this heated AFC South rivalry.
Meanwhile, the Houston Texans present a tougher challenge, having swept the Colts in back-to-back seasons behind a fierce defense, although doubts persist about C.J. Stroud's quarterback play. The real test might come from the Jacksonville Jaguars, who have surged with Trevor Lawrence’s breakout, a loaded receiving corps, and a strong defensive unit. Will the Colts finally snap their 11-year road drought in Jacksonville, or is another sweep on the horizon? AFC South supremacy hangs in the balance.